Zum Hauptinhalt springen

Klimakterium

Zuletzt bearbeitet: Zuletzt revidiert:
Zuletzt revidiert von:


Definition:
Das Klimakterium umfasst den Zeitraum um die Menopause und die Zeit danach.
Häufigkeit:
Zum Zeitpunkt der Menopause sind die Frauen in Deutschland im Median 51 Jahre alt.
Symptome:
Die typischen Symptome sind Blutungsstörungen, Hitzewallungen und vermehrte Schweißausbrüche, evtl. psychische Symptome, mit der Zeit auch Folgesymptome einer urogenitalen Atrophie der Schleimhäute.
Befunde:
Der klinische Befund kann eine atrophische Vaginalschleimhaut sein.
Diagnostik:
Zusatzuntersuchungen sind im Allgemeinen nicht erforderlich.
Therapie:
Bei den meisten Frauen ist eine Behandlung nicht erforderlich; evtl. kann eine niedrig dosierte Hormontherapie über einen möglichst kurzen Zeitraum gegeben werden. Bei Unverträglichkeit, Kontraindikation oder auf Wunsch der Patientin können andere Therapieverfahren eingesetzt werden.
  • Deutsche Gesellschaft für Gynäkologie und Geburtshilfe (DGGG). Peri- und Postmenopause – Diagnostik und Interventionen. AWMF-Leitlinie Nr. 015-062. S3, Stand 2020. www.awmf.org 
  • Dachverband Osteologie. Prophylaxe, Diagnostik und Therapie der Osteoporose. AWMF-Leitlinie Nr. 183-001. S3, Stand 2017. www.awmf.org 
  1. Palacios S, Henderson VW, Siseles N, Tan D, Villaseca P. Age of menopause and impact of climacteric symptoms by geographical region. Climacteric. 2010 Oct;13(5):419-28. doi: 10.3109/13697137.2010.507886. www.ncbi.nlm.nih.gov  
  2. Deutsche Gesellschaft für Gynäkologie und Geburtshilfe (DGGG). Peri- und Postmenopause - Diagnostik und Interventionen. AWMF-Leitlinie Nr. 015-062, S3, Stand 2020. www.awmf.org  
  3. Porter M, Penney G, Russell D, Russell E, Templeton A. A population based survey of women's experience of the menopause. Br J Obstet Gynaecol 1996; 103: 1025-8. PubMed  
  4. Deutsches Institut für Medizinische Dokumentation und Information (DIMDI): ICD-10-GM Version 2020. Stand 20.09.2019; letzter Zugriff 01.08.2020. www.dimdi.de  
  5. Dewhurst CJ, de Koos EB, Ferreira HP. The resistant ovary syndrome. Br J Obstet Gynaecol 1975;82:341-5 PubMed  
  6. Avis NE, Crawford SL, Greendale G, et al. Duration of menopausal vasomotor symptoms over the menopause transition. JAMA Intern Med. 2015. doi: 10.1001/jamainternmed.2014.8063 DOI  
  7. Manson JE, Martin KA. Postmenopausal hormone-replacement therapy. N Engl J Med 2001; 345: 34-40. PubMed  
  8. MacLennan AH, Broadbent JL, Lester S, Moore V. Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes. The Cochrane Library, Jan 21, 2009. CD002978. Cochrane (DOI)  
  9. O'Connor KA, Ferrel R, Brindle E, et al. Progesterone and ovulation across stages of the transition to menopause. Menopause 2009; 16: 1178-87. PubMed  
  10. Kemmler W, Häberle L, von Stengel S. Effects of exercise on fracture reduction in older adults : A systematic review and meta-analysis. Osteoporos Int. 2013 Jan 10. Epub ahead of print. pubmed.ncbi.nlm.nih.gov  
  11. Daley A, Stokes-Lampard H, Thomas A, MacArthur C. Exercise for vasomotor menopausal symptoms. Cochrane Database of Systematic Reviews 2014, Issue 11. Art. No.: CD006108. DOI: 10.1002/14651858.CD006108.pub4 DOI  
  12. Daley A, Thomas A, Roalfe A, et al. The effectiveness of exercise as treatment for vasomotor menopausal symptoms: randomised controlled trial. BJOG. 2014 PMID: 25516405 PubMed  
  13. Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM). Hormonersatztherapie: PRAC schließt die Überprüfung neuer Informationen über das bekannte Brustkrebsrisiko ab. 15.05.2020 www.bfarm.de  
  14. Furness S, Roberts H, Marjoribanks J, et al. Hormone therapy in postmenopausal women and risk of endometrial hyperplasia. Cochrane Database Syst Rev 2012 Aug 15;8:CD000402. Cochrane (DOI)  
  15. Suckling JA, Kennedy R, Lethaby A, Roberts H. Local oestrogen for vaginal atrophy in postmenopausal women. The Cochrane Library. Nov, 2010. CD001500.pub2. Cochrane (DOI)  
  16. Rote-Hand-Brief zu Linoladiol N® (Estradiol): Risiken in Verbindung mit einer systemischen Exposition. 20.02.2020. www.bfarm.de  
  17. Shams T, Firwana B, Habib F, et al. SSRIs for Hot Flashes: A systematic review and meta-analysis of randomized trials. J Gen Intern Med. 2013 Jul 26 PMID: 23888328 PubMed  
  18. Pinkerton JV, Constantine G, Hwang E, Cheng RF; for the Study 3353 Investigators. Desvenlafaxine compared with placebo for treatment of menopausal vasomotor symptoms: a 12-week, multicenter, parallel-group, randomized, double-blind, placebo-controlled efficacy trial. Menopause. 2013;20:28-37. PubMed  
  19. Pinkerton JV, Archer DF, Guico-Pabia CJ, Hwang E, Cheng RF. Maintenance of the efficacy of desvenlafaxine in menopausal vasomotor symptoms: a 1-year randomized controlled trial. Menopause 2013;20:38-46. PubMed  
  20. Archer DF, Pinkerton JV, Guico-Pabia CJ, Hwang E, Cheng RF; for the Study 3353 Investigators. Cardiovascular, cerebrovascular, and hepatic safety of desvenlafaxine for 1 year in women with vasomotor symptoms associated with menopause. Menopause 2013;20:47-56. PubMed  
  21. Joffe H, Guthrie KA, LaCroix AZ, et al. Low-dose estradiol and the serotonin-norepinephrine reuptake inhibitor venlafaxin for vasomotor symptoms. A randomized clinical trial. JAMA Internal Medicine| 2014. doi:10.1001/jamainternmed.2014.1891 DOI  
  22. Caraci F, Crupi R, Drago F, Spina E. Metabolic drug interactions between antidepressants and anticancer drugs: focus on selective serotonin reuptake inhibitors and hypericum extract. Curr Drug Metab 2011;12:570-7. PubMed  
  23. Heiss G et al. Health risks and benefits 3 years after stopping randomized treatment with estrogen and progestin. JAMA 2008; 9: 1036–1045. pubmed.ncbi.nlm.nih.gov  
  24. Gartlehner G, Patel SV, Feltner C, et al. Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Women: Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA 2017 Dec 12; 318(22): 2234-2249. pmid:29234813 PubMed  
  25. Manson JE, Chlebowski RT, Stefanick ML, et al. Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials. JAMA 2013; 310: 1353-68. doi:10.1001/jama.2013.278040 DOI  
  26. Nelson HD, Walker M, Zakher B, Mitchell J. Menopausal hormone therapy for the primary prevention of chronic conditions: A systematic review to update the U.S. Preventive Services Task Force recommendations. Ann Intern Med 2012; 157: 1-10. Annals of Internal Medicine  
  27. Marjoribanks J, Farquhar C, Roberts H, et al. Long term hormone therapy for perimenopausal and postmenopausal women. Cochrane Database of Systematic Reviews 2012; 7: CD004143. Cochrane (DOI)  
  28. Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52705 women with breast cancer and 108411 women without breast cancer. Lancet 1997; 350:1047-59. PubMed  
  29. Million Women Study Collaborators. Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 2003; 362: 419 - 27. PubMed  
  30. Chlebowski RT, Manson JE, Anderson GL, et al. Estrogen plus progestin and breast cvancer incidence and mortality in the Women`s Health Initiative observational study. J Natl Cancer Inst 2013; 105: 526-35. PubMed  
  31. Collaborative Group on Hormonal Factors in Breast Cancer. Type and timing of menopausal hormone therapy and breast cancer risk: individual participant meta-analysis of the worldwide epidemiological evidence. Lancet 2019. pmid:31474332. www.ncbi.nlm.nih.gov  
  32. Collaborative Group on Epidemiological Studies of Ovarian Cancer. Menopausal hormone use and ovarian cancer risk: individual participant meta-analysis of 52 epidemiological studies. Lancet 2015. doi:10.1016/S0140-6736(14)62458-2 DOI  
  33. Liu B, Beral V, Balkwill A et al. Gallbladder disease and use of transdermal versus oral hormone replacement therapy in postmenopausal women: prospective cohort study. BMJ 2008; 337: a386. pubmed.ncbi.nlm.nih.gov  
  34. Middendorf K, Burges A, Strauss A, Hepp H. Uterusmyome--Behandlungsoptionen aus der Sicht des Gynäkologen Uterine fibroids--therapy from the point of view of the gynaecologist. Radiologe. 2003;43(8):615-623. doi:10.1007/s00117-003-0936-1 DOI  
  35. Boardman HMP, Hartley L, Eisinga A, et al. Hormone therapy for preventing cardiovascular disease in post-menopausal women. Cochrane Database of Syst Rev 2015; 3: CD002229. doi:10.1002/14651858.CD002229.pub4 DOI  
  36. Chlebowski RT, Schwartz AG, Wakelee H, et al. Oestrogen plus progestin and lung cancer in postmenopausal women (Women's health initiative trial): a post-hoc analysis of a randomised controlled trial. Lancet 2009; 374: 1243-51. PubMed  
  37. Shumaker SA, Legault C, Kuller L, et al. Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women. Women's Health Initiative Memory Study. JAMA 2004; 291: 2947-58. jamanetwork.com  
  38. Espeland MA, Rapp SR, Shumaker SA, et al. Conjugated equine estrogens and global cognitive function in postmenopausal women. Women's Health Initiative Memory Study. JAMA 2004; 291: 2959-68. pubmed.ncbi.nlm.nih.gov  
  39. Manson JE, Aragaki AK, Rossouw JE, et al. Menopausal Hormone Therapy and Long-term All-Cause and Cause-Specific Mortality. JAMA 2017; 318: 927-38. pmid:28898378 PubMed  
  40. Gupta J, Kai J, Middleton L, et al. Levonorgestrel intrauterine system versus medical therapy for menorrhagia. N Engl J Med 2013; 368: 128-37. New England Journal of Medicine  
  41. Nelson HD. Commonly used types of postmenopausal estrogen for treatment of hot flashes. Scientific review. JAMA 2004; 291:1610-620. pubmed.ncbi.nlm.nih.gov  
  42. Hitchcock CL, Prior JC. Oral micronized progesterone for vasomotor symptoms--a placebo-controlled randomized trial in healthy postmenopausal women. Menopause 2012 Aug; 19(8): 886-93. PubMed  
  43. Marjoribanks J, Farquhar C, Roberts H, Lethaby A. Long term hormone therapy for perimenopausal and postmenopausal women. The Cochrane Library, 11 July, 2012. CD004143.pub4. Cochrane (DOI)  
  44. Bachmann G, Bouchard C, Hoppe D, et al. Efficacy and safety of low-dose regimens of conjugated estrogens cream administered vaginally. Menopause 2009; 16: 719-27. PubMed  
  45. Holmberg L, Iversen OE, Rudenstam CM, et al. HABITS Study Group. Increased risk of recurrence after hormone replacement therapy in breast cancer survivors. J Natl Cancer Inst 2008;100:475-82. PubMed  
  46. Jackson RD, LaCroix AZ, Gass M, et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 2006; 354: 669-83. New England Journal of Medicine  
  47. Canonico M, Plu-Bureau G, Lowe GDO, Scarabin P-Y. Hormone replacement therapy and risk of venous thromboembolism in postmenopausal women: systematic review and meta-analysis . BMJ 2008; 336: 1227-31. PubMed  
  48. Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA. 2002;288:321-333. PubMed  
  49. Hsia J, Langer RD, Manson JE, et al. Conjugated equine estrogens and coronary heart disease. The Women's Health Initiative. Arch Intern Med 2006; 166(3): 357-365. PubMed  
  50. Waters DD, Alderman EL, Hsia J, et al. Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women. A randomized controlled trial. JAMA 2002; 288: 2432-40. PubMed  
  51. Grady D, Herrington D, Bittner V, et al, for the HERS Research Group. Cardiovascular disease outcomes during 6.8 years of hormone therapy: heart and estrogen/progestin replacement study follow-up (HERS II). JAMA 2002; 288: 49-57. PubMed  
  52. van Driel CM, Stuursma A, Schroevers MJ, Mourits MJ, de Bock GH. Mindfulness, cognitive behavioural and behaviour-based therapy for natural and treatment-induced menopausal symptoms: a systematic review and meta-analysis. BJOG. 2019;126(3):330-339. doi:10.1111/1471-0528.15153 DOI  
  53. Lethaby A, Marjoribanks J, Kronenberg F, Roberts H, Eden J, Brown J. Phytoestrogens for menopausal vasomotor symptoms. Cochrane Database of Systematic Reviews 2013, Issue 12. Art. No.: CD001395. DOI: 10.1002/14651858.CD001395.pub4. DOI  
  54. Dodin S, Blanchet C, Marc I et al. Acupuncture for menopausal hot flushes. Cochrane Database of Systematic Reviews 2013. Issue 7. Art. No.: CD007410. DOI: 10.1002/14651858.CD007410.pub2. www.cochranelibrary.com  
  55. Lund KS, Siersma V, Brodersen J, Waldorff FB. Efficacy of a standardised acupuncture approach for women with bothersome menopausal symptoms: a pragmatic randomised study in primary care (the ACOM study). BMJ Open 2019; 9: e023637. pmid:30782712. www.ncbi.nlm.nih.gov  
  56. Sternfeld B et al. Efficacy of exercise for menopausal symptoms: A randomized controlled trial. Menopause 2014; 21:330. doi: 10.1097/GME.0b013e31829e4089 DOI  
  57. Newton KM, et al. Efficacy of yoga for vasomotor symptoms: A randomized controlled trial. Menopause 2014; 21:339. doi: 10.1097/GME.0b013e31829e4baa DOI  
  58. Cohen LS, et al. Efficacy of omega-3 for vasomotor symptoms treatment: A randomized controlled trial. Menopause 2014; 21:347. doi: 10.1097/GME.0b013e31829e40b8 DOI  
  59. Dachverband Osteologie. Prophylaxe, Diagnostik und Therapie der Osteoporose. AWMF-Leitlinie Nr. 183-001, S3, Stand 2017. www.awmf.org  
  • Thomas M. Heim, Dr. med., Wissenschaftsjournalist, Freiburg
  • Erika Baum, Prof. Dr. med., Professorin für Allgemeinmedizin, Biebertal (Review)