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Churg-Strauss-Syndrom (eosinophile Granulomatose mit Polyangiitis, EGPA)

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Definition:
Idiopathische systemische Vaskulitis von kleinen und mittelgroßen Arterien, begleitet von schwerem Asthma und Eosinophilie.
Häufigkeit:
Inzidenz etwa 2–4:1.000.000 in USA und Westeuropa.
Symptome:
Asthma bronchiale als Erstsymptom, im Verlauf systemische Ausbreitung.
Befunde:
Stark variable Organmanifestationen, u. a. kutan, kardial und renal.
Diagnostik:
Nachweis von Asthma sowie Eosinophilie im Blutbild, zudem klinische Manifestationen der Vaskulitis, ggf. Biopsie.
Therapie:
Immunsuppression.
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  • Lino Witte, Dr. med., Arzt in Weiterbildung, Innere Medizin, Frankfurt