Zerebrale Sinus- und Venenthrombose
Zuletzt revidiert:
Zuletzt revidiert von:Kristine Scheibel
Definition:
Thrombose in einer zentralen Gehirnvene oder einem Sinusgefäß mit Entwicklung einer venösen Abflussstörung
Häufigkeit:
Selten. Liegt weniger als 1 % aller Schlaganfälle zugrunde.
Symptome:
In der Regel Kopfschmerzen, Übelkeit, evtl. Krampfanfall, Lähmung, Bewusstseinsveränderungen.
Befund:
Stauungspapille. Neurologische Befunde.
Diagnose:
Die Diagnose erfolgt vorzugsweise per MRT.
Therapie:
Antikoagulation mittels Heparin und Vitamin-K-Antagonisten.
- Deutsche Gesellschaft für Neurologie. Zerebrale Sinus- und Venenthrombose. AWMF-Leitlinie Nr. 030-098. S2k, Stand 2018. www.awmf.org
- Deutsche Gesellschaft für Neurologie. Zerebrale Sinus- und Venenthrombose. AWMF-Leitlinie Nr. 030-098l_Sk2, Stand 2018. www.awmf.org
- McElveen WA. Cerebral Venous Thrombosis. Medscape, last updated 2015. emedicine.medscape.com
- Masuhr F, Mehraein S, Einhäupl K. Cerebral venous and sinus thrombosis. J Neurol 2004; 251: 11-23. PubMed
- Stam J. Thrombosis of the cerebral veins and sinuses. N Eng J Med 2005; 352: 1791-8. PubMed
- Ferro JM, Canhão P. Etiology, clinical features, and diagnosis of cerebral venous thrombosis. UpToDate, last updated Jan 2, 2013. UpToDate
- Johnsen H, Vorhaug A, Kvistad K. Cerebral venetrombose - diagnostikk og behandling. Tidsskr Nor Lægeforen 2007; 127: 1069-73. PubMed
- Biousse V, Ameri A, Bousser MG. Isolated intracranial hypertension as the only sign of cerebral venous thrombosis. Neurology 1999; 53: 1537. Neurology
- Pendl T, Gattringer T. Die zerebrale Sinusvenenthrombose: Eine seltene zerebrovaskuläre Erkrankung vorwiegend junger Patientinnen. Zeitschrift für Gefäßmedizin 2019; 16: 5-9. www.kup.at
- Fink JN, McAuley DL. Cerebral venous sinus thrombosis: a diagnostic challenge. Int Med J 2001; 31: 384-90. PubMed
- Agostoni E. Headache in cerebral venous thrombosis. Neurol Sci 2004; 25 Suppl 3: 206.
- Ferro JM, Canhão M. Treatment and prognosis of cerebral venous thrombosis. UpToDate, last updated May 05, 2015. UpToDate
- Benamer HT, Bone I. Cerebral venous thrombosis: anticoagulants or thrombolytic therapy? J Neurol Neurosurg Psychiatry 2000; 69: 427-30. PubMed
- Results from RE-SPECT CVT published - first trial of NOAC in cerebral venous thrombosis; Ingelheim, Germany, 4 September 2019 www.boehringer-ingelheim.com
- Yamini B, Loch Macdonald R, Rosenblum J. Treatment of deep cerebral venous thrombosis by local infusion of tissue plasminogen activator. Surg Neurol 2001; 55: 340-6. PubMed
- Ferro, JM, Canhão, P, Stam, J, et al; ISCVT Investigators. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke 2004; 35: 664. Stroke
- Ferro JM, Correia M, Pontes C, et al. Cerebral vein and dural sinus thrombosis in Portugal: 1980-1998. Cerebrovasc Dis 2001; 11: 177. PubMed
- Carrier M, Lazo-Langner A, Shivakumar S, et al. Screening for occult cancer in unprovoked venous thromboembolism. N Engl J Med. 2015. PMID: 26095467 PubMed
- Coutinho J, de Bruijn SFTM, deVeber G, Stam J. Anticoagulation for cerebral venous sinus thrombosis. Cochrane Database of Systematic Reviews 2011, Issue 8. Art. No.: CD002005. DOI: 10.1002/14651858.CD002005.pub2. DOI
- Ciccone A, Canhão P, Falcão F, Ferro JM, Sterzi R. Thrombolysis for cerebral vein and dural sinus thrombosis. Cochrane Database of Systematic Reviews 2004, Issue 1. Art. No.: CD003693. DOI: 10.1002/14651858.CD003693.pub2. DOI
- Schwedt TJ, Matharu MS, Dodick DW. Thunderclap Headache. Lancet Neurol 2006; 5: 621-31. PubMed
- Grover M. Cerebral Venous Thrombosis as a cause of acute headache. J Am Board Fam Pract 2004; 17: 295-8. PubMed
- Lancon, JA, Killough, KR, Tibbs, RE, et al. Spontaneous dural sinus thrombosis in children. Pediatr Neurosurg 1999; 30: 23. PubMed
- Linn J, Ertl-Wagner B, Seelos KC, Strupp M, Reiser M, Brückmann H, Brüning R. Diagnostic value of multidetector-row CT angiography in the evaluation of thrombosis of the cerebral venous sinuses. Am J Neuroradiol 2007; 28: 946-52. PubMed
- Bousser MG. Cerebral venous thrombosis: diagnosis and management. J Neurol 2000; 247: 252-8. PubMed
- Coutinho JM, Stam J. How to treat cerebral venous and sinus thrombosis. J Thromb Haemost 2010; 8:877. PubMed
- de Bruijn SF, Stam J. Randomized, placebo-controlled trial of anticoagulant treatment with low-molecular-weight heparin for cerebral sinus thrombosis. Stroke 1999; 30: 484-8. Stroke
- Feher G, Illes Z, Komoly S, Hargroves D. Novel oral anticoagulants in the treatment of cerebral venous thrombosis. Int Angiol. 2015. PMID: 25994451 PubMed
- Marshall AL, Connors JM. Anticoagulation for noncardiac indications in neurologic patients: comparative use of non-vitamin k oral anticoagulants, low-molecular-weight heparins, and warfarin. Curr Treat Options Neurol. 2014 Sep;16(9):309 . pmid:25038005 PubMed
- Kristine Scheibel, Dr. med., Fachärztin für Allgemeinmedizin, Norderney
- Terje Johannessen, professor i allmennmedisin, redaktør NEL