Lino Witte

Dr. med.

Bertil Christensson

professor och överläkare

Kurt Østhuus Krogh

specialist inom barnsjukdomar

Lew DP, Waldvogel FA. Osteomyelitis. Lancet 2004; 364: 369-79.

Hatzenbuehler J, Pulling TJ. Diagnosis and management of osteomyelitis. Am Fam Physician 2011; 84: 1027-33.

--&gt; https://www.awmf.org/leitlinien/detail/ll/012-033.html

Deutsche Gesellschaft für Unfallchirurgie. Akute und chronische exogene Osteomyelitis langer Röhrenknochen des Erwachsenen. AWMF-Leitlinie Nr. 012-033. Stand 2017.

Mylona E, Samarkos M, Kakalou E, Fanourgiakis P, Skoutelis A. Pyogenic vertebral osteomyelitis: a systematic review of clinical characteristics. Semin Arthritis Rheum 2009; 39: 10-7.

--&gt; https://www.ncbi.nlm.nih.gov/pubmed/16829765

Concia E, Prandini N, Massari L, et al. Osteomyelitis: clinical update for practical guidelines. Nucl Med Commun 2006; 27(8): 645-60.

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Girschick PH. Chronische nicht-bakterielle Osteomyelitis/rezidivierende multifokale Osteomyelitis. Orphanet, Stand 2013.

Schilling F. Das SAPHO-Syndrom. Paris, Orphanet 2016

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Kremers HM, Nwojo ME, Ransom JE, et al. Trends in the epidemiology of osteomyelitis: a population-based study, 1969 to 2009. J Bone Joint Surg Am 2015; 97(10): 837-45.

Gutierrez K. Bone and joint infections in children. Pediatr Clin North Am 2005; 52: 779-94.

--&gt; https://emedicine.medscape.com/article/1348767

Kushner S. Osteomyelitis. Medscape, last updated Mar 01, 2018.

Aragón-Sánchez J, Lázaro-Martínez JL, Quintana-Marrero1 Y, et al. Are diabetic foot ulcers complicated by MRSA osteomyelitis associated with worse prognosis? Outcomes of a surgical series. Diabet Med 2009; 26: 552-5.

--&gt; https://www.ncbi.nlm.nih.gov/pubmed/12966271

Cierny G III, Mader JT, Penninck JJ. A clinical staging system for adult osteomyelitis. Clin Orthop Relat Res 2003; (414): 7-24.

--&gt; https://www.ncbi.nlm.nih.gov/pubmed/16297731

Calhoun JH, Manring MM. Adult osteomyelitis. Infect Dis Clin North Am 2005; 19(4): 765-86.

Pineda C, Espinosa R, Pena A. Radiographic imaging in osteomyelitis: the role of plain radiography, computed tomography, ultrasonography, magnetic resonance imaging, and scintigraphy. Semin Plast Surg 2009; 23: 80-9.

Kapoor A, Page S, Lavalley M, Gale DR, Felson DT. Magnetic resonance imaging for diagnosing foot osteomyelitis: a meta-analysis. Arch Intern Med 2007; 167: 125-32.

Termaat MF, Raijmakers PG, Scholten HJ, Bakker FC, Patka P, Haarman HJ. The accuracy of diagnostic imaging for the assessment of chronic osteomyelitis: a systematic review and meta-analysis. J Bone Joint Surg Am 2005; 87: 2464-71.

Saavedra-Lozano J, Mejias A, Ahmad N, et al. Changing trends in acute osteomyelitis in children: impact of methicillin-resistant Staphylococcus aureus infections. J Pediatr Orthop 2008; 28: 569-75.

Pollak AN, Jones AL, Castillo RC, Bosse MJ, MacKenzie EJ; LEAP Study Group. The relationship between time to surgical debridement and incidence of infection after open high-energy lower extremity trauma. J Bone Joint Surg Am 2010; 92: 7-15.

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Darouiche RO, Landon GC, Klima M, Musher DM, Markowski J. Osteomyelitis associated with pressure sores. Arch Intern Med 1994; 154: 753-58.

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--&gt; https://www.ncbi.nlm.nih.gov/pubmed/12045656

Gross T, Kaim AH, Regazzoni P, et al. Current concepts in posttraumatic osteomyelitis: a diagnostic challenge with new imaging options. J Trauma 2002; 52(6): 1210-9.

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--&gt; https://www.ncbi.nlm.nih.gov/pubmed/16799390

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Chen WL, Chang WN, Chen YS, et al. Acute community-acquired osteoarticular infections in children: high incidence of concomitant bone and joint involvement. J Microbiol Immunol Infect 2010; 43: 332-8.

--&gt; https://www.awmf.org/leitlinien/detail/ll/082-006.html

Paul-Ehrlich-Gesellschaft für Chemotherapie e.V. (PEG). Kalkulierte parenterale Initialtherapie bakterieller Erkrankungen bei Erwachsenen - Update 2018. AWMF-Leitlinie 082-006. Stand 2017.

Roblot F, Besnier JM, Juhel L, et al. Optimal duration of antibiotic therapy in vertebral osteomyelitis. Semin Arthritis Rheum 2007; 36: 269-77.

--&gt; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926389/

Castellazzi L, Mantero M, Esposito S. Update on the Management of Pediatric Acute Osteomyelitis and Septic Arthritis. Int J Mol Sci 2016; 17(6): 855.

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Belthur MV, Birchansky SB, Verdugo AA, et al. Pathologic fractures in children with acute Staphylococcus aureus osteomyelitis. J Bone Joint Surg Am 2012; 94(1): 34-42.

--&gt; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923996/

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Norden C, Nelson JD, Mader JT, Calandra GB. Evaluation of new anti-infective drugs for the treatment of infections of prosthetic hip joints. Clin Infect Dis 1992; 15 :(suppl 1) S177-81.

Erregerinduzierte Infektion des Knochens, endogen oder exogen bedingt.

21,8 Fälle auf 100.000 Personenjahre. Bei Kindern vor allem akute Osteomyelitis, bei älteren Personen chronische Osteomyelitis.

Fieber, Schüttelfrost, reduzierter Allgemeinzustand und lokale Entzündungszeichen.

Lokale Entzündungszeichen, reduzierte Beweglichkeit in benachbarten Gelenken.

Röntgen in 2 Ebenen sowie MRT, ggf. ergänzt durch CT.

Bei akuter Form i. v. Antibiotikatherapie, bei chronischer Form operative Sanierung.

Osteomyelitis, bakterielle

Allgemeine Informationen

Diagnostik

Diagnostische Kriterien

Differenzialdiagnosen

Anamnese

Klinische Untersuchung

Laboruntersuchungen

Bildgebung

Mikrobiologie

Therapie

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Allgemeines zur Therapie

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Komplikationen

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Patienteninformationen in Deximed

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