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Chronische muskuloskelettale Schmerzen bei Kindern

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  • Deutsche Gesellschaft für Kinder- und Jugendmedizin e. V. (DGKJ). Muskuloskelettale Schmerzen bei Kindern und Jugendlichen – Ein Algorithmus zur differenzialdiagnostischen Abklärung eines häufigen Leitsymptoms in der Kinder- und Jugendmedizin. AWMF-Leitlinie Nr. 027-073. S2k, Stand 2020. www.awmf.org 
  • Gesellschaft für Pädiatrische Radiologie e. V. (GPR). Rückenschmerz (nicht traumatisch) bei Kindern – Bildgebende Diagnostik. AWMF-Leitlinie Nr. 064-012. S1, Stand 2020. www.awmf.org 
  • Gesellschaft für Pädiatrische Radiologie (GPR). Bewegungseinschränkung bei Kindern – Bildgebende Diagnostik. AWMF-Leitlinie Nr.064-008. S1, Stand 2020. www.awmf.org 
  1. Junnila JL, Cartwright VW. Chronic musculoskeletal pain in children: Part I. Initial evaluation. Am Fam Physician 2006; 74: 115-22. PubMed  
  2. Junnila JL, Cartwright VW. Chronic musculoskeletal pain in children. Part II: Rheumatologic causes. Am Fam Physician 2006; 74: 293-300. American Family Physician  
  3. Gesellschaft für Pädiatrische Onkologie und Hämatologie. Muskuloskelettale Schmerzen bei Kindern und Jugendlichen: Algorithmus zur differenzialdiagn. Abklärung eines onkologischen Leitsymptoms. AWMF-Leitlinie Nr. 025-032. Stand 2013. www.sciencedirect.com  
  4. Sherry DD, Malleson PN. Nonrheumatic musculoskeletal pain, and idiopathic musculoskeletal pain syndromes. In: Cassidy JT, Petty RE, eds. Textbook of Pediatric Rheumatology. 4th ed. Philadelphia, Pa.: Saunders, 2001: 362-81.
  5. Roth-Isigkeit A, Thyen U, Stöven H, et. al. Pain among children and adolescents: restrictions in daily living and triggering factors. Pediatrics 2005; 115: e152-62. pubmed.ncbi.nlm.nih.gov  
  6. Gesellschaft für Pädiatrische Radiologie e.V. (GPR). Rückenschmerz (nicht traumatisch) bei Kindern - Bildgebende Diagnostik. AWMF-Leitlinie 064-012. Stand 2020. www.awmf.org  
  7. Deutsche Gesellschaft für Kinder- und Jugendmedizin e.V. (DGKJ). Muskuloskelettale Schmerzen bei Kindern und Jugendlichen – Ein Algorithmus zur differenzialdiagnostischen Abklärung eines häufigen Leitsymptoms in der Kinder- und Jugendmedizin. AWMF-Leitlinie Nr. 027-073. Stand 2020. www.awmf.org  
  8. Mulvey MR, Macfarlane GJ, Beasley M, et al. Modest association of joint hypermobility with disabling and limiting musculoskeletal pain: results from a large-scale general population-based survey. Arthritis Care Res (Hoboken) 2013; 65(8): 1325-33. www.ncbi.nlm.nih.gov  
  9. Shultz SP, Anner J, Hills AP. Paediatric obesity, physical activity and the musculoskeletal system. Obes Rev 2009; 10: 576-82. PubMed  
  10. Chan G, Chen CT. Musculoskeletal effects of obesity. Curr Opin Pediatr 2009; 21: 65-70. PubMed  
  11. Lowe RM, Hashkes PJ. Growing pains: a noninflammatory pain syndrome of early childhood. Nat Clin Pract Rheumatol 2008; 4(10): 542-9. www.ncbi.nlm.nih.gov  
  12. Noonan KJ, Farnum CE, Leiferman EM, Lampl M, Markel MD, Wilsman NJ. Growing pains: are they due to increased growth during recumbency as documented in a lamb model? J Pediatr Orthop 2004; 24: 726-31. PubMed  
  13. Evans AM, Scutter SD. Prevalence of "growing pains" in young children. J Pediatr 2004; 145: 255-8. PubMed  
  14. Picchietti D, Allen RP, Walters AS, et al. Restless legs syndrome: prevalence and impact in children and adolescents--the Peds REST study. Pediatrics 2007; 120(2): 253-66. www.ncbi.nlm.nih.gov  
  15. Steliarova-Foucher E, Stiller C, Kaatsch P, Berrino F, Coebergh JW, Lacour B, et al. Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970s (the ACCIS project): an epidemiological study. Lancet 2004; 364: 2097-105. PubMed  
  16. Redaelli A, Laskin BL, Stephens JM, Botteman MG, Pashos CL. A systematic literature review of the clinical and epidemiological burden of acute lymphoblastic leukaemia (ALL). Eur J Cancer Care 2005; 14: 53-62. pubmed.ncbi.nlm.nih.gov  
  17. Wagner N, Dannecker G. Pädiatrische Rheumatologie. Berlin Heidelberg: Springer-Verlag, 2014.
  18. Petty RE, Smith JR, Rosenbaum JT. Arthritis and uveitis in children. A pediatric rheumatology perspective. Am J Ophthalmol 2003; 135: 879-84. PubMed  
  19. Gesellschaft für Pädiatrische Radiologie (GPR). Bewegungseinschränkung bei Kindern - Bildgebende Diagnostik. AWMF-Leitlinie Nr.064-008. Stand 2020. www.awmf.org  
  20. Lawrence RC, Helmick CG, Arnett FC, Deyo RA, Felson DT, Giannini EH, et al. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 1998; 41: 778-99. PubMed  
  21. Krause A., Reaktive Arthritis. Deutsche Rheuma-Liga Bundesverband e.V., 2015 www.rheuma-liga.de  
  22. Kuhn A, Bonsmann G, Anders H-J, Herzer P, Tenbrock K, Schneider M. The Diagnosis and Treatment of Systemic Lupus Erythematosus. Dtsch Arztebl Int. 2015 Jun 19;112(25):423-32 www.ncbi.nlm.nih.gov  
  23. McGhee JL, Kickingbird LM, Jarvis JN. Clinical utility of antinuclear antibody tests in children. BMC Pediatr 2004; 4: 13. PubMed  
  24. Klein-Gitelman M, Reiff A, Silverman ED. Systemic lupus erythematosus in childhood. Rheum Dis Clin North Am 2002; 28: 561-77. PubMed  
  25. Rivest C, Lew RA, Welsing PM, Sangha O, Wright EA, Roberts WN, et al. Association between clinical factors, socioeconomic status, and organ damage in recent onset systemic lupus erythematosus. J Rheumatol 2000;27:680-4. www.ncbi.nlm.nih.gov  
  26. Yurkovich M, Vostretsova K, Chen W, Aviña-Zubieta JA. Overall and cause-specific mortality in patients with systemic lupus erythematosus: a meta-analysis of observational studies. Arthritis Care Res (Hoboken) 2014; 66: 608-16 www.ncbi.nlm.nih.gov  
  27. Sundel R, Szer I. Vasculitis in childhood. Rheum Dis Clin North Am 2002; 28: 625-54. PubMed  
  28. Gedalia A. Henoch-Schönlein purpura. Curr Rheumatol Rep 2004; 6(3): 195-202. www.ncbi.nlm.nih.gov  
  29. Pachman LM, Hayford JR, Chung A, Daugherty CA, Pallansch MA, Fink CW, et al. Juvenile dermatomyositis at diagnosis: clinical characteristics of 79 children. J Rheumatol 1998; 25: 1198-204. PubMed  
  30. Shehata R, al-Mayouf S, al-Dalaan A, al-Mazaid A, al-Balaa S, Bahabri S. Juvenile dermatomyositis: clinical profile and disease course in 25 patients. Clin Exp Rheumatol 1999; 17: 115-8. PubMed  
  31. Malleson PN, Beauchamp RD. Rheumatology: 16. Diagnosing musculoskeletal pain in children. CMAJ 2001; 165: 183-8. pubmed.ncbi.nlm.nih.gov  
  32. Cabral DA, Tucker LB. Malignancies in children who initially present with rheumatic complaints. J Pediatr 1999; 134: 53-7. PubMed  
  33. Trapani S, Grisolia F, Simonini G, Calabri GB, Falcini F. Incidence of occult cancer in children presenting with musculoskeletal symptoms: a 10-year survey in a pediatric rheumatology unit. Semin Arthritis Rheum 2000; 29: 348-59. PubMed  
  34. Sherry DD, Stein LD, Reed AM, Schanberg LE, Kredich DW. Prevention of leg length discrepancy in young children with pauciarticular juvenile rheumatoid arthritis by treatment with intraarticular steroids. Arthritis Rheum 1999; 42: 2330-4. PubMed  
  35. Mehlman CT, Crawford AH, McMath JA. Pediatric vertebral and spinal cord tumors: a retrospective study of musculoskeletal aspects of presentation, treatment, and complications. Orthopedics 1999; 22: 49-56. PubMed  
  36. Gardner GC, Kadel NJ. Ordering and interpreting rheumatologic laboratory tests. J Am Acad Orthop Surg 2003; 11: 60-7. PubMed  
  37. Malleson PN, Mackinnon MJ, Sailer-Hoeck M, Spencer CH.. Review for the generalist: The antinuclear antibody test in children - When to use it and what to do with a positive titer. Pediatr Rheumatol Online J 2010; 8: 27. PubMed  
  38. Bas S, Genevay S, Meyer O, Gabay C. Anti-cyclic citrullinated peptide antibodies, IgM and IgA rheumatoid factors in the diagnosis and prognosis of rheumatoid arthritis. Rheumatology 2003; 42: 677-80. pubmed.ncbi.nlm.nih.gov  
  39. Bas S, Perneger TV, Seitz M, Tiercy JM, Roux-Lombard P, Guerne PA. Diagnostic tests for rheumatoid arthritis: comparison of anti-cyclic citrullinated peptide antibodies, anti-keratin antibodies and IgM rheumatoid factors. Rheumatology 2002; 41: 809-14. pubmed.ncbi.nlm.nih.gov  
  40. Hoffman IE, Peene I, Pottel H, Union A, Hulstaert F, Meheus L, et al. Diagnostic performance and predictive value of rheumatoid factor, anti-citrullinated peptide antibodies, and the HLA shared epitope for diagnosis of rheumatoid arthritis. Clin Chem 2005; 51: 261-3. PubMed  
  41. Karmazyn B. Ultrasound of pediatric musculoskeletal disease: from head to toe. Semin Ultrasound CT MR 2011; 32(2): 142-50. www.ncbi.nlm.nih.gov  
  42. Trueworthy RC, Templeton KJ. Malignant bone tumors presenting as musculoskeletal pain. Pediatr Ann 2002; 31: 355-9. PubMed  
  43. Tuten HR, Gabos PG, Kumar SJ, Harter GD. The limping child: a manifestation of acute leukemia. J Pediatr Orthop 1998; 18: 625-9. PubMed  
  44. Kuseler A, Pedersen TK, Gelineck J, Herlin T. A 2 year follow up study of enhanced magnetic resonance imaging and clinical examination of the temporomandibular joint in children with juvenile idiopathic arthritis. J Rheumatol 2005; 32: 162-9. PubMed  
  45. Argyropoulou MI, Fanis SL, Xenakis T, Efremidis SC, Siamopoulou A. The role of MRI in the evaluation of hip joint disease in clinical subtypes of juvenile idiopathic arthritis. Br J Radiol 2002; 75: 229-33. pubmed.ncbi.nlm.nih.gov  
  46. Lanna CC, Tonelli E, Barros MV, Goulart EM, Mota CC. Subclinical rheumatic valvitis: a long-term follow-up. Cardiol Young 2003; 13: 431-8. PubMed  
  47. American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines. Guidelines for the management of rheumatoid arthritis: 2002 update. Arthritis Rheum 2002; 46: 328-46. PubMed  
  48. Nell VP, Machold KP, Eberl G, Stamm TA, Uffmann M, Smolen JS. Benefit of very early referral and very early therapy with disease-modifying anti-rheumatic drugs in patients with early rheumatoid arthritis. Rheumatology 2004; 43: 906-14. pubmed.ncbi.nlm.nih.gov  
  • Lino Witte, Dr. med., Arzt in Weiterbildung, Orthopädie und Unfallchirurgie, Münster